Abstract 114: Potential Risk Factors for Worsening Abdominal Well-Being after Abdominal Flap Breast Reconstruction: There’s No Such Thing As a Free Tummy Tuck

Sarday, M ay 6, 2017 persists until the infection is cleared by antibiotic therapy and/or surgical management. While the acute phase response is essential for tissue healing and regeneration, over-activation of the acute phase response is maladaptive and may lead to systemic complications including thrombosis, organ failure, and disseminated intravascular coagulation. In the setting of severe infections, continuous activation of the APR has the potential to become dysregulated. The magnitude of the acute phase reaction can be quantified by both the peak concentration of CRP as well as the total duration of CRP elevation through calculating the area under the curve. We hypothesize that the area under the CRP curve is increased in musculoskeletal infection due to continual tissue injury and we believe that this cumulative response over time correlates with the incidence of complications.